PHA Exfoliants: A Gentler Alternative to AHA?
Skincare Science · 2026
PHA Exfoliants: A Gentler Alternative to AHA?
Polyhydroxy acids (PHAs) are a newer-generation exfoliating ingredient. They have larger molecular structures than glycolic acid, work more slowly, and are often better tolerated by sensitive skin.
What PHAs are
Polyhydroxy acids (PHAs) — including gluconolactone and lactobionic acid — exfoliate the skin like the better-known alpha-hydroxy acids (AHAs glycolic and lactic). The key difference is molecule size: PHAs are physically larger, so they enter the skin more slowly and tend to cause less stinging on application.
What the research shows
Edison and colleagues published a comparative study in 2004 in Cutis reporting that a polyhydroxy-acid skin-care regimen produced antiaging effects comparable to an alpha-hydroxy-acid regimen — but with a different tolerability profile.[1] PHAs are often the first exfoliant we suggest for sensitive skin or for users with rosacea-prone skin who have struggled with traditional acids.
Press & Glow® at Verdo
Medik8® Press & Glow® uses gluconolactone (a PHA) in a daily exfoliating tonic format. The line is designed for low-irritation daily use and is available in original and refill formats.
How to layer PHA in your routine
- Morning or evening, after cleansing.
- Press onto the skin using a cotton pad or hands.
- Build slowly. Even gentle exfoliants can sensitise if started at full frequency. Begin with 3–4 nights a week.
- Always use SPF in the morning. All exfoliants increase sun sensitivity.
Featured Medik8® exfoliating tonics
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Shop Press & Glow® →References
- Edison BL et al. (2004). A polyhydroxy acid skin care regimen provides antiaging effects comparable to an alpha-hydroxyacid regimen. Cutis. View
