Copper Peptides (GHK-Cu): What the Research Says About This Skincare Ingredient

Copper Peptides (GHK-Cu): What the Research Says About This Skincare Ingredient

Peptides are everywhere in skincare right now, and copper peptides are among the most studied of them. Here is what the research says, in plain terms.

What copper peptides are

GHK is a very small, naturally occurring peptide, glycyl-histidyl-lysine, that binds copper to form the complex known as GHK-Cu. It is present in the body and, according to the research, its levels decline as we age (Pickart et al., 2015, PMID 26236730).

What the research shows

A review of the peptide reports that GHK-Cu stimulates the synthesis of collagen, elastin and glycosaminoglycans and supports the function of dermal fibroblasts, the cells that build and maintain the skin's structure (Pickart and Margolina, 2018, PMID 29986520). In cosmetic products, the review literature associates it with improvements in skin elasticity, density and firmness and a reduction in fine lines (Pickart et al., 2015, PMID 26236730). It is worth being clear that much of this evidence comes from reviews and laboratory work rather than large clinical trials.

A closer look in the lab

In a laboratory study using skin cells and an ex-vivo skin model, GHK-Cu combined with hyaluronic acid increased the synthesis of collagen IV, a component of the layer where the outer and deeper skin meet (Jiang et al., 2023, PMID 37062921). This is a mechanism study in skin models, not a clinical trial in people, but it helps explain why the two ingredients often appear together.

How to use them

  • Copper peptides sit in the gentle, supportive part of a routine, so they suit most skin types.
  • They pair naturally with hydrating ingredients like hyaluronic acid.
  • As with any new active, introduce it gradually and give your skin time to adjust.

At Verdo we stock Medik8 Copper PCA Peptides, Medik8 Liquid Peptides, and the Medik8 Advanced Pro Collagen and Peptide Cream.

Disclaimer: This article is for general information only and is not medical advice. The studies cited are from peer-reviewed journals and are provided for educational context. Individual results vary. Speak with a qualified healthcare professional or dermatologist before changing your routine. Verdo Cosmetics makes no therapeutic claims about the products or services mentioned.

Frequently asked questions

What are copper peptides in skincare?
Copper peptides usually refer to GHK-Cu, a complex of the small natural peptide GHK (glycyl-histidyl-lysine) with copper. GHK is present in the body and its levels decline with age (Pickart et al., 2015). In skincare it is used as a supportive, gentle active.
What do copper peptides do for skin?
A review reports that GHK-Cu stimulates synthesis of collagen, elastin and glycosaminoglycans and supports dermal fibroblasts (Pickart and Margolina, 2018), and in cosmetic use has been associated with improved elasticity, density and firmness and reduced fine lines (Pickart et al., 2015). Much of this evidence is from reviews and laboratory studies rather than large clinical trials.
Can I use copper peptides with other ingredients?
Copper peptides are generally gentle and pair well with hydrating ingredients such as hyaluronic acid. A laboratory study found GHK-Cu and hyaluronic acid together increased collagen IV synthesis in skin models (Jiang et al., 2023). Introduce any new active gradually.
Are copper peptides suitable for sensitive skin?
Copper peptides are considered a supportive, well-tolerated ingredient that suits most skin types, but everyone is different. Patch test a new product first, introduce it slowly, and speak to a professional if your skin is reactive or you are unsure.
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